Anthocyanins from fruits may benefit the cardiovascular system through platelet chemokines
Anthocyanins have been shown to positively affect the functioning of many organs and systems, including the immune , nervous and cardiovascular systems.
A new study published in Nutrition and Metabolism has now revealed another possible mechanism through which anthocyanins, a type of flavonoid, benefit the cardiovascular system.
In the study which involved 146 participants between 40 and 65 years, supplementation with 320mg of purified anthocyanins, or about 100g of fresh blueberries and blackcurrants over a 24 week period led to significant reductions in platelet chemokine levels. The reduction of chemokines was accompanied by lower levels of inflammatory markers in people with elevated cholesterol levels.
According to the Chinese researchers from the Sun Yat-sen University, the platelet chemokines are involved in immune responses, inflammatory reactions, and other processes which influence the development of atherosclerosis.
Reductions of two platelet chemokines levels in particular, CXCL and CCL2, positively correlated with decreases in serum low-density lipoprotein cholestrol (LDL-C), high-sensitivity C-reactive protein, and beta interleukin-1 .
Lower levels of the chemokine CXCL8 also corresponded to increased high-density lipoprotein cholesteron (HDL-C).
The researchers conluded as follows: „ The present study supports the notion that platelet chemokines are promising targets of anthocyanins in the prevention of atherosclerosis.“
This study confirms results from previous researches, including a 2015 study in which black elderberry anthocyanins were found to improve markers of HDL cholesterol function in hyperlipidermic mice, thereby potentially improving the function of the cardiovascular system.